The Small Molecule Screening Facility (SMSF) fosters collaborative drug discovery research between chemists, biologists and physician scientists that leads to the identification of new small molecules that inhibit disease targets and phenotypes in biochemical and cellular models relevant to any therapeutic area.
To learn more about our services and discuss your needs, contact Michael Hoffmann (fmhoffma@wisc.edu) or Gene Ananiev (geananiev@wisc.edu). Free estimates provided.
More about SMSF
Contact Us
Faculty Leader: Michael Hoffmann, fmhoffma@wisc.edu, 608-263-2890
Facility Manager: Gene Ananiev, geananiev@wisc.edu, 608-265-8687
Computational Modeling and Virtual Screening:
Scott Wildman, swildman@wisc.edu
Ken Satyshur, satyshur@wisc.edu
Spencer Ericksen, ssericksen@wisc.edu
Room 6003 WIMR
Services Offered
High-Throughput Screening
Assay Ready Plates
Seahorse Metabolism Analysis
Mycoplasma Detection
Molecular Modeling and Virtual Screening
Equipment and Pricing
The Small Molecule Screening Facility (SMSF) has specialized equipment dedicated to drug discovery. Scientists from UW-Madison, other universities or private companies may receive training on some pieces of the shared equipment
Acknowledgments
Funding received from the UWCCC Cancer Center Support Grant (CCSG) for published research, including the use of UWCCC Shared Resources to generate or analyze data, or conduct clinical trials, needs to reference the UWCCC. See Acknowledging UWCCC in Publications, Posters, and Presentations.
View the UW Research Expertise website for more information on other UW–Madison laboratory facilities that provide state-of-the-art instrumentation and expert scientific staff.
SMSF's Latest Publications
- Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris
- Machine Learning Consensus Scoring Improves Performance Across Targets in Structure-Based Virtual Screening
- BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells
- A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein-Protein Interactions in an Academic Screening Facility
- Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells
SMSF's Latest Posts
Machine Learning in Drug Discovery
August 28, 2017SMSF Provides Assay Ready Plates
Tip-less acoustic liquid handling using the Labcyte ECHO can transfer as little as 2.5nL of DMSO compound solution between plates. This capability allows us to offer assay ready plates for screening at low cost. The …
August 28, 2017New SMSF Screening Library
The SMSF now has a 100,000 compound library from Life Chemicals ready for screening. The recent addition of our fourth subset of 25,000 compounds complements the previous sets (added 1/2009, 10/2009 and 9/2015). These sets …
August 28, 2017- More DDC posts
- More SMSF posts