The Small Molecule Screening Facility (SMSF) fosters collaborative drug discovery research between chemists, biologists and physician scientists that leads to the identification of new small molecules that inhibit disease targets and phenotypes in biochemical and cellular models relevant to any therapeutic area.
To learn more about our services and discuss your needs, contact Tom Polaske (polaske@wisc.edu). Free estimates provided.
Notice: The SMSF is undergoing rates evaluation. We will be implementing a comprehensive 5% equipment and personnel rate increase on February 1, 2024.
More about SMSF
Contact Us
Faculty Leader: Prof. Tim Bugni
Facility Manager: Tom Polaske, Ph.D., polaske@wisc.edu, 715-889-4215
Computational Modeling and Virtual Screening:
Spencer Ericksen, Ph.D., ssericksen@wisc.edu
Room 6003 WIMR
Services Offered
High-Throughput Screening
Assay Ready Plates
Seahorse Metabolism Analysis
Mycoplasma Detection
Molecular Modeling and Virtual Screening
Equipment and Pricing
The Small Molecule Screening Facility (SMSF) has specialized equipment dedicated to drug discovery. Scientists from UW-Madison, other universities or private companies may receive training on some pieces of the shared equipment
Acknowledgments
Funding received from the UWCCC Cancer Center Support Grant (CCSG) for published research, including the use of UWCCC Shared Resources to generate or analyze data, or conduct clinical trials, needs to reference the UWCCC. See Acknowledging UWCCC in Publications, Posters, and Presentations. Please acknowledge “UWCCC Small Molecule Screening Facility” for any work supported by the SMSF. Thank you!
Sample Acknowledgment
“The author(s) thank the University of Wisconsin Carbone Cancer Center Small Molecule Screening Facility, supported by P30 CA014520, for use of its facilities and services.”
View the UW Research Expertise website for more information on other UW–Madison laboratory facilities that provide state-of-the-art instrumentation and expert scientific staff.
Recent SMSF Publications
- Practical Model Selection for Prospective Virtual Screening
- Biemamides A-E, Inhibitors of the TGF-β Pathway That Block the Epithelial to Mesenchymal Transition
- Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris
- Machine Learning Consensus Scoring Improves Performance Across Targets in Structure-Based Virtual Screening
- A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein-Protein Interactions in an Academic Screening Facility
SMSF's Latest Posts
Utilize the Small Molecule Screening Facility’s LabCyte Echo 650-Access Workstation
The PerkinElmer (previously LabCyte) Echo 650-Access acoustic liquid handling workstation is the ultimate solution for precision and efficiency in compound management, high throughput screening (HTS), and cell-based and biochemical assays. Potential applications for the Echo-Access …
February 14, 2025SMSF Collaboration News
The Small Molecule Screening Facility (SMSF) just received word that a manuscript submitted to Biometrics was accepted. This work emerges from a collaborative project with graduate student Peng Yu (lead author) from Prof. Michael A. …
February 10, 2022- More DDC posts
- More SMSF posts