It is important to consider the source of aggregation in your samples to properly address the issue. Adhesion can often be counteracted by removing divalent cations. However, the activity of DNAse requires divalent cations. Using EGTA instead of EDTA may allow magnesium ions to interact with DNAse while still partially mitigating adhesion.
Updated 9/18/17
Minimizing Aggregates in Samples
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