The Genome Editing and Animal Models Shared Resource (GEAM) provides affordable genome editing services to the members of UW Carbone. These include genome editing design, generation of novel models (mice, rats, cell lines), cryopreservation, recovery and rederivation of unique mouse and rat lines. It uses the personnel, facilities and equipment within the UW Biotechnology Center.
Genome edited models provide one of the most valuable tools for unraveling the molecular and genetic mechanisms of cancer and for evaluating new strategies for cancer treatment and prevention. This facility has the technical expertise in genome editing, embryo manipulation, and animal husbandry necessary to efficiently generate customized models.
Contact Us
Faculty Leader: Christopher Bradfield
Facility Co-Manager: C. Dustin Rubinstein
Facility Co-Manager: Kathy Krentz, (608) 890-3785
Lab: (608) 262-9495
Lab Locations
425 Henry Mall
Madison WI 53706
Advanced Gene Editing: 3240 Biotech
Animal Models: 3220 Biotech
Services and Facilities
GEAM Services
We have extensive expertise in:
- CRISPR/Cas9 design, consultation, and synthesis for mice, rats, and cell lines
- Generation of transgenic mice and rats by pronuclear microinjection
- Generation of mouse models from embryonic stem (ES) cells
- Cryopreservation of mouse and rat embryos and sperm
- Rederivation of rodent model strains
- Other molecular biology and animal services related to transgenic and genome editing technology
We ensure the customized projects are ideally suited for your needs.
The Biotech Center
The Genome Editing Lab and Animal Models Core are both housed in the Biotech Center.
Genome Editing Lab
Provides seamless access to the full toolkit of genome editing possibilities, including CRISPR screening and modeling.
Animal Models Core
Generates novel, highly relevant, genome edited or transgenic animal models (mice, rat, swine) and provides state-of-the-art reproductive biology services that enable animal model banking, recovery, and sharing.
GEAM Scientific Accomplishments
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2025
Deng C, Elujoba-Bridenstine A, Song AT, Ceplina RM, Ostheimer CJ, Pellitteri Hahn MC, Scarlett CO, Saka S, Pan X, Tamplin OJ. GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells Stem Cell Reports, 2025
2024
Heaton AR, Burkard NJ, Sondel PM, Skala MC. Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation imaging. Biophotonics Discov. 2024
Copeland SE, Snow SM, Wan J, Matkowskyj KA, Halberg RB, Weaver BA. MAD1 upregulation sensitizes to inflammation-mediated tumor formation. PLoS Genet. 2024
Acknowledgements
Any published research which received funding from the UWCCC Cancer Center Support Grant (CCSG), including the use of UWCCC Shared Resources to generate or analyze data or conduct clinical trials, must reference the UWCCC. See Acknowledging UWCCC in Publications, Posters and Presentations. Please acknowledge “UWCCC Genome Editing and Animal Models Shared Resource” for any work supported by GEAM. Thank you!
Sample Acknowledgment
“The author(s) thank the University of Wisconsin Carbone Cancer Center Genome Editing and Animal Models Shared Resource, supported by P30 CA014520, for use of its facilities and services.”