Genome edited models provide one of the most valuable tools for unraveling the molecular and genetic mechanisms of cancer and for evaluating new strategies for cancer treatment and prevention. This facility has the technical expertise in genome editing, embryo manipulation, and animal husbandry necessary to efficiently generate customized models.
Services currently provided by the Genome Editing and Animal Models Shared Resource include: CRISPR/Cas9 design, consultation, and synthesis for mice, rats, and cell lines Generation of transgenic mice and rats by pronuclear microinjection Generation of mouse models from embryonic stem (ES) cells Cryopreservation of mouse and rat embryos and sperm Rederivation of rodent model strains Other…
GEAM’s selected scientific accomplishments include Dr. Michael Gould’s research to identify genetic determinants of breast cancer risk and strategies for breast cancer prevention, Dr. Jing Zhang’s work on the role of Kras on hematopoietic malignancies and leukemia and Dr. Paul Lambert’s research on the roles of the human papillomavirus oncogenes in head, neck and cervical…
Any published research which received funding from the UWCCC Cancer Center Support Grant (CCSG), including the use of UWCCC Shared Resources to generate or analyze data or conduct clinical trials, must reference the UWCCC. See Acknowledging UWCCC in Publications, Posters and Presentations. Please acknowledge “UWCCC Genome Editing and Animal Models Shared Resource” for any work supported by GEAM. Thank you!
“The author(s) thank the University of Wisconsin Carbone Cancer Center Genome Editing and Animal Models Shared Resource, supported by P30 CA014520, for use of its facilities and services.”