Through close integration with the UW Health enterprise, WiscShare/TSB BioBank utilizes an IRB-approved protocol (2023-1237 ) to collect, process, store, and distribute a broad array of human-derived biospecimens that can meet the varying needs of individual investigators. However, prospective collections may have limitations due to biospecimen availability and logistical circumstances in obtainment. Upon developing a complete understanding of both research and clinical needs, an appropriate approach for obtaining a specimen is identified and specific workflows are established to accommodate both clinical workflows and specimen processing requirements. Please contact us to explore how we can support your work.
FAQ
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What kind of research does the WiscShare protocol cover?
WiscShare is an umbrella protocol for the collection and distribution of biospecimens for purposes of research but does not in itself serve as approval for any research per se. To utilize our specimens, you will need to be sure that they meet the definition of not-human subjects research or obtain appropriate approval through the IRB. Our Not-Human Subjects Research Evaluation Tool (NHSR Eval) can help you get started on your way to regulatory approval or you can contact us here.
How do I get biological specimens from the TSB Biobank?
After you have completed our Not Human Subjects Research Evaluation Tool, a prospective specimen request can be submitted in the Translational Science BioCore – BioBank iLab page. We will then contact you regarding next steps for assessing feasibility and establishing workflows.
Am I eligible to use WiscShare specimens?
If your work meets the definition of “not human subject’s research”, your work is outside IRB purview, and we can serve you through our honest broker system. If you have knowledge of a subject’s identity or are involved in obtaining a specimen, your work will not meet this definition, but you will be eligible to use specimens after obtaining appropriate approval through the IRB. Our Not Human Subjects Research Evaluation Tool (NHSR Eval) can help you get started on your way to regulatory approval or you can contact us here for guidance.
Am I guaranteed to get the specimens I want?
We meet with teams directly to develop a complete understanding of research needs and clinical challenges so that we can determine the best approach for obtaining a specimen. Then we develop customized workflows to accommodate both clinical workflows and specimen processing requirements. However, it is important to note that all prospective collections may have limitations due to biospecimen availability and logistical circumstances in obtainment. For example, we can be limited by rarity of a condition or the need to use samples entirely for clinical purposes. If WiscShare cannot be utilized to obtain the specimen you need, we can discuss the possibility of other approaches and connect you with other teams, if applicable.
Can I get clinical data?
Yes! Our honest broker system supports distribution of clinical annotations in a deidentified manner. If you need to access this information directly, you will need IRB approval first.
Basic Information on Genomic Data Sharing for WiscShare/TSB BioBank Samples
- Research requiring genomic data sharing cannot be performed using samples from patients who have not consented to their use if they were collected after 2015. Therefore, it is essential that investigators interested in utilizing samples from the TSB Biobank for genetic/genomic research disclose such information at the time of project intake so that appropriate samples can be provided.
- When preparing to deposit genomic data into repositories, investigators will need to obtain a certificate from the IRB.
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- WiscShare source documents used in current workflows indicate in what year a consent was signed for all samples.
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- For samples obtained prior to the implementation of the current WiscShare source documents in 2024, investigators should inquire with the TSB Biobank on when participants consented to the WiscShare protocol. The IRB will then use this information to determine what certificate(s) are necessary and provide them accordingly.
Can WiscShare specimens be included in work requiring Genomic Data Sharing?
WiscShare participants who have enrolled in recent years have consented to use of their specimens for genomic sequencing and associated data sharing platforms. However, this is not true for all specimens historically and requirements vary according to the time that specimens were collected. It is essential that investigators interested in utilizing samples from the TSB Biobank for genetic/genomic research disclose such information at the time of project intake so that appropriate samples can be provided. Once your research is completed and you are preparing to deposit genomic data into repositories, you will need to work directly with your assigned IRB staff reviewer to obtain a genomic data sharing certificate, including a change of protocol within Arrow. TSB BioBank can provide you with the information the IRB will need to prepare certificate(s).
- WiscShare source documents used in current workflows indicate in what year a consent was signed for all samples. If you have these documents for all your samples, then you do not need to ask for additional information from TSB BioBank.
- For samples obtained prior to the implementation of the current WiscShare source documents in 2024, investigators should inquire with the TSB Biobank on when participants consented to the WiscShare protocol. The IRB will then use this information to determine what certificate(s) are necessary and provide them accordingly.
- For more information on how to obtain a Certification for NIH Genomic Data Sharing please click here to learn more.