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March 16, 2021
Big Data and Omics in Cancer Research
This year with our theme of Big Data and Omics in Cancer Research we come together for the Virtual Carbone Cancer Center Research Retreat to share our visions for the future of cancer research and care. We will also report on progress in our current research so we can celebrate and learn from each other.
The contributions from each individual to our Carbone Cancer Center team—from trainees, to administrators, researchers, clinicians and faculty — allow us to move forward together and be the driving force for research, prevention, and treatment initiatives critical to defeating cancer in Wisconsin and around the world.
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Welcome and Keynote - Dr. Bartha Knoppers
Dr. Howard Bailey and Retreat Co-chairs Drs. Shaneda Warren Anderson and Christian Capitini
Cancer Data Sharing: Of Screening, Stratification, and Scores
Bartha Knoppers, PhD
Breakout Sessions
Development of Precision Therapeutics at the UW Medicinal Chemistry Center
A guide for investigators, exemplified by a project presentation
John Feltenberger, PhD and Weiping Tang, PhD
Practical Bioinformatics Tools for Cancer Omics
Irene Ong, PhD
Precision Oncology: Patient and Clinician Perspectives
Mark Burkard, MD, PhD and patient
Nataliya Uboha, MD, PhD and patient
Dusty Deming, MD
Trainee Presentations
Yang Hu – Paclitaxel induces micronucleation and activates pro-inflammatory cGAS-STING signaling in triple-negative cancer
Hannah Micek – The Influence of Extracellular Matrix on Metastatic Multicellular Detachment in High-Grade Serous Ovarian Cancer
Nicholas Mohrdieck – An immune co-stimulatory vaccine, with adoptive transfer of natural killer cells and immune inhibition blockade, after allogeneic bone marrow transplant, delays and reduces
Monica Cho – CD155 blockade boosts alloreactive natural killer cell antitumor effects against osteosarcoma
Arika Feils – INV721, a bispecific SNIPER antibody targeting GD2 and B7H3, improves tumor specific immunotherapeutic antibody targeting of neuroblastoma tumors
Nan Sethakorn, MD, PhD – LumeNEXT: A microfluidic organ-on-chip model of the bone niche in solid tumor metastases to assay stroma-mediated drug resistance
Maria Virumbrales-Munoz, PhD – 3D Patient-Specific Microfluidic Models of Primary Head and Neck Cancer To Evaluate Individual Drug Responses
Ngai Ting Chan – Transcriptional elongation machinery controls vulnerability of breast cancer cells to PRC2 inhibitors
Poster Session
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Session #1: Cancer Immunotherapy: Adoptive Cell Therapy
Session #2: Cancer Immunotherapy: Biologics
Session #3: Immune-related Adverse Events
Session #4: Single Cell Analyses/Cancer Stem Cells
Session #5: Precision Medicine
Session #6: Molecular Oncology
Session #7: Tumor Microenvironment
Session #8: Cancer Virology
Session #9: Clinical Oncology
Session #10: Population Health
Keynote - Dr. Mia Levy
From N-of-1 to N-of-All: Clinical Decision Making in the Era of Precision Medicine & Big Data
Mia Levy, MD, PhD
Breakout Sessions & Closing Remarks
Breakout One
Using a Population-Health Data Infrastructure to Collect Multi-Omic Data to Address Cancer Health Disparities
Kristen Malecki, PhD
Breakout Two
Solid and Liquid Biomarkers to Personalize Treatment in Prostate Cancer
Shuang (George) Zhao
Breakout Three
Shared Resources for Big Data
Bioinformatics Resource Center
DNA Sequencing Facility
Mass Spectrometry/ Proteomics Facility
Cancer Metabolomics
Data Science Hub
Microbiome Hub
Announcement of awards for trainee presentations
Dr. Bailey, Dr. Warren Anderson and Dr. Capitini
Keynote Speakers
Bartha Maria Knoppers, PhD, is an expert on the ethical aspects of genetics, genomics and biotechnology. Professor Knoppers’ research focuses on human rights as a driver for data sharing.
Mia A. Levy, MD, PhD, is the Director of the Cancer Center at Rush University Medical Center and the System Vice President for Cancer Services at Rush System for Health. Dr. Levy’s research mission is to develop and disseminate learning cancer systems that deliver data and knowledge driven clinical decision support across the continuum of cancer care and research.