Clinical Research Central Office
The UW Carbone Clinical Research Central Office (CRCO) provides infrastructure to support our clinical research investigators.
Care for patients at UW Carbone involves a multidisciplinary team approach. Disease Oriented Teams (DOTs) within the CRCO assist investigators in conducting clinical research trials and facilitating patient care activities. Each DOT has a designated faculty leader, and participants include UW Carbone Scientific Program members, research staff, and other UW faculty. Integrating Scientific Programs in the DOTs fosters inter- and intra-programmatic interactions and disease specific interests that bridges the translation of laboratory discovery to clinical application.
DOTs meet regularly and interested research faculty are encouraged to actively participate. Contact the DOT leader or program manager for more information or view the DOT standing meeting schedule (NetID login required).
Interested in clinical trials? Learn more.
What We Do
- Provide budget feasibility and Medicare Compliance Review
- Assist with research billing compliance questions and concerns
- Generate and negotiate externally-sponsored research budgets on an as needed basis
- Support and facilitate study activation reviews with clinical services
- Coordinate visits for external sponsored-research monitors
- Provide data management and/or regulatory services for research groups as needed
- Coordinate and support the enrollment of participants to available clinical trials within DOTs
- Register Investigator Initiated Trials (IIT) to the NCI via the NCI Clinical Trials Reporting Program. Contact CT Reporting
The mission of the Data and Safety Monitoring System (DSMS) is to provide oversight to assure compliance with applicable federal regulations, institutional policies and procedures, and Good Clinical Practice in the conduct of all clinical research at UW Carbone.
The DSMS is comprised of one main committee, the Data and Safety Monitoring Committee (DSMC). It is responsible for the regular review and monitoring of all on-going clinical research at UW Carbone. The Committee meets regularly to review quality assurance reports, including internal audits and response reviews, as well as noncompliance reports and serious adverse events.
DSMC members are UW Carbone faculty and staff who represent multiple disciplines with a breadth of experience in clinical research and regulatory affairs.
Contact DSMC
- Staff Onboarding, Education, and Training (requires NetID login).
- Investigator Resources (requires NetID login).
- Coordinate clinical research conducted by UW researchers at affiliate sites within our Regional and National Network
- Assist with data verification and support for external sites conducting research
- Provide assistance in development of investigator-initiated trials
- Review and assist with LOI submissions
- Collect and analyze study activation metrics
- Provide education and support for sponsor-investigator INDs
- Provide UW Carbone-specific protocol templates (e.g., Interventional, Observational, Translational) by contacting CRCO
The mission of the Protocol Review and Monitoring System (PRMS) is to oversee the scientific aspects of cancer-related studies at UW Carbone. This system is comprised of one main committee, the Protocol Review and Monitoring Committee (PRMC), which meets twice monthly. It is responsible for evaluating the scientific merit, resource allocation, trial priority, and trial progress (via accrual monitoring) of new and ongoing clinical and translational research studies. Additionally, the PRMC reviews cancer-related clinical research to ensure an appropriate Data and Safety Monitoring Plan is included in each proposal.
PRMC members are UW Carbone faculty and staff researchers who represent a wide range of disciplines with a breadth of experience in clinical research.
Proposed studies must have the support of the DOT prior to submission to the PRMC. Investigators and staff that are not part of the DOTs work with the PRMC Coordinator to subject the required forms. Contact the PRMC Coordinator with any questions.
Leadership
Associate Director of Clinical Research: Nataliya Uboha
Assistant Director of Clinical Research: Sarah Stewart
Contact the CRCO
Acknowledging UW Carbone
If you receive funding from the UW Carbone Core Grant for published research including the use of UW Carbone Shared Resources to generate or analyze data, or conduct clinical trials, please reference our Researcher Tools and Support.