At the Office of Translational Research Services, we help researchers put promising ideas and discoveries on the path toward improved human health. OTRS supports researchers from early- to late- stage development by providing collaboration opportunities, assistance with agreements, multi-investigator grants, tissue acquisition, and IRB applications.
More about OTRS
Collaboration
Translating scientific discoveries into practice often requires a multidisciplinary team. Let OTRS assist with establishing collaborations.
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Connect to Resources
UWCCCC Shared Services
- Find and connect with the right research resource
UW Campus
- Office of Vice Chancellor for Research and Graduate Education Centers and Cores
- Research Project Resource Guide
- Wisconsin Discovery Portal – Researcher Directory
National /NCI
- Helping Extramural Innovators Reach the Clinic: NCI Developmental Therapeutics Program Presentation for 2018 AACR meeting
- NCI Developmental Therapeutics Program
- NExT Pipeline supporting promising drug discovery and development projects
- The BrIDGs program assists researchers in advancing promising therapeutic agents through late-stage pre-clinical development toward an Investigational New Drug (IND) application and clinical testing
Event Coordination
Administrative support for the planning, coordination, and implementation of interdisciplinary scientific seminars, meetings, and retreats.
Recent events include 2021 UWCCC Research Retreat and BadgerConnect.
Industry
- Facilitate and coordinate visits with Industry and Pharmaceutical Companies for presentation of drug development pipelines
- Establish collaboration opportunities
Recent visits include Eli Lilly, Janssen, Novartis, Bristol Myers-Squibb, Sun Pharma Advanced Research Company, Tesaro, Taiho Oncology.
Drug Discovery Consultation Panel
PIs may apply through SMApply
Next request for applications coming summer 2019.
The UWCCC Drug Discovery Consultation Panel is a service for principal investigators to help prioritize UWCCC/Programmatic drug development and provide consultation on basic drug discovery and prospective advice on target advancement.
The Consultation Panel is a panel of expert private sector, pharmacy, scientific, and oncology experts. The board consists of external and internal researchers with significant experience in industry and academic cancer drug development.
A project development team will review proposals to determine project milestones, identify key gaps, and strengthen the project’s likelihood of advancing toward new therapeutics, diagnostics, devices, or treatment approaches.
OTRS provides administrative support for the Drug Discovery Consultation Panel by:
- Coordinating a panel of expert consultants
- Managing the review and selection process
IRB Related Services
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Regulatory Support
OTRS provides support for all required regulatory submissions (pdf opens in new tab) to the UWCCC Protocol Review and Monitoring Committee (PRMC) and the UW Institutional Review Board (IRB).
OTRS also provides assistance with development of protocol documents that are required for IRB submission.
OTRS will work closely with the research team throughout all stages of the regulatory review process, and will maintain contact with the research team throughout the life of the project to ensure that all PRMC and IRB requirements are maintained.
Basic Science/Translational Projects
Recent projects for which OTRS has provided regulatory support:
- Study of Markers in Human Breast Tissue
- Development of Patient-Derived Cultures and Xenografts for Translational Studies
- Study of Indicators of Oxidative Stress in Human Prostate Specimens
- Fusion Genes Predict Prostate Cancer Recurrence
- Tissue Analysis to Measure CIN and Mitotic Abnormalities in Primary and Metastatic Breast Cancer
Application Process
Begin the process of working with OTRS on a regulatory application (pdf opens in new tab)
More Information
To request more information about the OTRS regulatory support service, please contact OTRS at (608) 262-8016 or email OTRS@uwcarbone.wisc.edu.
Agreements
An authorized institutional official must sign all agreements. OTRS will facilitate the review, negotiation, and execution of agreements for Carbone Cancer Center members that govern relationships with other academic institutions, industry partners, and other collaborators.
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Agreements for Materials/Data/Confidentiality
If you need any assistance with an agreement, please contact nonfunded_agreements@uwcarbone.wisc.edu with your request.
Material Transfer Agreements (MTAs)
- For incoming or outgoing research material
- MTAs protect the rights of both parties in the transfer of research materials
- Click here for forms and more information
Confidential Disclosure Agreements (CDAs)
- Also known as Non-Disclosure Agreements (NDAs), for protection of confidential information
- Needed for transfer of confidential information between a company and University investigators
- Must be signed by a University official
Intellectual Property Agreements (IPAs)
- For compliance with sponsored research agreement terms and conditions
- A school or college may require staff and students to enter into an IPA
- For disclosure of inventions and compliance with provisions of sponsored research agreements
Invention Disclosures (WARF)
Invention disclosures report (IDRs)
- For equity review and potential protection of your discovery
- All discoveries by UW-Madison faculty, staff, or students must be disclosed in an IDR and filed with WARF
- Once WARF processes the IDR, it forwards the invention disclosure form to the Office of the Vice Chancellor for Research and Graduate Education, which is responsible for determining the disposition of the intellectual property rights and for any required notifications.
- Following that, the inventor may have the option to work with WARF for patent protection
- IDRs/patent protection ideally should be in place before public disclosure
Investigational New Drugs & Devices
INDs and IDEs
- Assist Clinical Trials Central Office with administrative support and management of UWCCC Investigational New Drugs (INDs) and Investigational Device Exemptions (IDEs)
- The Investigational New Drug (IND) Application fulfills the following two regulatory requirements:
- Federal law requires that a drug be FDA approved before it can be transported across state lines. The IND is a technical request for exemption from the federal law.
- The IND is a request for permission to conduct clinical trials by supplying relevant non-clinical, CMC and previous human experience (if applicable) in the application.
- ICTR IND/IDE Consultation service
Facilities Use
Facilities Use Agreements delineate non-UW use of shared resource facilities by defining terms and conditions for use and guidelines for establishing effective academic-industrial partnerships. If you need any assistance with a non-funded agreement, please contact nonfunded_agreements@uwcarbone.wisc.edu with your request.
Multi-Investigator Grants
Planning for multi-investigator grants:
- Planning, implementation and organizational management for
SPORE grants, Program Project Grants, and multi-investigator translational research grants - Developing and overseeing a coordinated and managed approach for the submission of multi-investigator translational research grant proposals
- Providing project management – facilitating meetings, coordinating with possible collaborators, and creating timelines.
- Provide expertise on compliance aspects of application
- Assist with writing administrative sections of grants
- Work with Pre-Award Office preparing biosketches, letters of support, and supporting documentation
- Track application status and provide additional requested documentation
- Potential Administrative Core management
- Assist with Progress Report preparation
How to acknowledge UW Carbone Cancer Center Shared Resources
Any published research which received funding from the UWCCC Cancer Center Support Grant (CCSG), including the use of UWCCC Shared Resources to generate or analyze data or conduct clinical trials, must reference the UWCCC. See Acknowledging UWCCC in Publications, Posters and Presentations.